Applications of HepG2 Cells in Toxicology Studies

HepG2 cells serve as a reliable in vitro model for assessing liver toxicity. Their human origin and hepatic enzyme activity allow researchers to evaluate the metabolism and hepatotoxic potential of new drugs. Unlike Vero cells, which lack liver-specific enzymes, HepG2 cells provide insights into cytochrome P450 pathways. This makes them essential in preclinical studies for predicting human liver responses, supporting drug development and regulatory safety assessments.